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Ceramide signalling
Stable Identifier
R-HSA-193681
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Ceramide signalling (Homo sapiens)
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In certain cell types, ligand binding to p75NTR leads to ceramide production, which can mediate either cell survival (e.g. in noecotical subplate neurons) or apoptosis (e.g. in oligodendrocytes). Low levels of ceramide are also able to stimulate axonal outgrowth in hippocampal neurons.
Literature References
PubMed ID
Title
Journal
Year
12676795
Trk receptors: roles in neuronal signal transduction
Reichardt, LF
,
Huang, EJ
Annu Rev Biochem
2003
Participants
Events
Sphingomyelinase is activated by the NGF:p75NTR complex
(Homo sapiens)
Production of ceramide which can activate JNK and other targets
(Homo sapiens)
Participates
as an event of
p75 NTR receptor-mediated signalling (Homo sapiens)
Event Information
Go Biological Process
apoptotic signaling pathway (0097190)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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