TRAF6 binds to p75NTR:NRIF

Stable Identifier
R-HSA-193669
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon neurotrophin stimulation, p75NTR interacts with the ubiquitin 3 ligase TRAF6 (TNF receptor-associated factor 6). It is unclear whether TRAF6 binds to p75NTR directly, or whether it needs to be recruited through an adaptor protein such as MyD88.Recruitment of NRIF and TRAF6 to p75NTR is followed by an interaction between the two cytoplasmic proteins, It is possible that the NRIF:TRAF6 interaction promotes formation of a multimeric signalling complex. TRAF6 appears to promote NRIF release from p75NTR

Literature References
PubMed ID Title Journal Year
14960584 A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF

Gentry, JJ, Rutkoski, NJ, Burke, TL, Carter, BD

J Biol Chem 2004
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