NRIF signals cell death from the nucleus

Stable Identifier
R-HSA-205043
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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NRIF signals cell death from the nucleus
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NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor.
Literature References
PubMed ID Title Journal Year
15721744 p75NTR--live or let die

Nykjaer, A, Petersen, CM, Willnow, TE

Curr Opin Neurobiol 2005
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Event Information
Go Biological Process
positive regulation of apoptotic process (0043065)
Orthologous Events
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Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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