CYP17A1 cleaves 17aHPROG to ANDST

Stable Identifier
R-HSA-193099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
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17Alpha-hydroxyprogesterone (17aHPROG), NADPH + H+, and O2 react to form 4-Androstene-3, 17-dione (ANDST), NADP+, H2O, and acetaldehyde. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), which also catalyzes 17-alpha-hydroxylation, catalyzes this lyase reaction.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
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