CYP17A1 cleaves 17aHPROG to ANDST

Stable Identifier
R-HSA-193099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

17Alpha-hydroxyprogesterone (17aHPROG), NADPH + H+, and O2 react to form 4-Androstene-3, 17-dione (ANDST), NADP+, H2O, and acetaldehyde. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), which also catalyzes 17-alpha-hydroxylation, catalyzes this lyase reaction.

Literature References
Participants
Participates
Catalyst Activity

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!