CYP17A1 17-hydroxylates PREG

Stable Identifier
R-HSA-193068
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
O2 + pregnenolone + reduced (NADPH--hemoprotein reductase) => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
ReviewStatus
5/5
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CYP17A1 17-hydroxylates PREG
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Pregnenolone (PREG) and NADPH + H+ react to form 17alpha-hydroxypregnenolone (17aHPREG), NADP+, and H2O. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane, catalyzes this reaction.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]

Physical Entity
CYP17A1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
steroid 17-alpha-monooxygenase activity (GO:0004508)
Orthologous Events
CYP17A1 17-hydroxylates PREG (Bos taurus)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Danio rerio)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Mus musculus)
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
CYP17A1 17-hydroxylates PREG (Sus scrofa)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-02-13)
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