CYP17A1 17-hydroxylates PREG

Stable Identifier
R-HSA-193068
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CYP17A1 17-hydroxylates PREG
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pregnenolone (PREG) and NADPH + H+ react to form 17alpha-hydroxypregnenolone (17aHPREG), NADP+, and H2O. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane, catalyzes this reaction.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]

Physical Entity
CYP17A1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
steroid 17-alpha-monooxygenase activity (GO:0004508)
Orthologous Events
CYP17A1 17-hydroxylates PREG (Bos taurus)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Danio rerio)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Mus musculus)
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
CYP17A1 17-hydroxylates PREG (Sus scrofa)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-02-13)
Cite Us!