Cholesterol is hydroxylated to 25-hydroxycholesterol

Stable Identifier
R-HSA-191983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Cholesterol is hydroxylated to 25-hydroxycholesterol
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The microsomal enzyme cholesterol 25-hydroxylase is a member of a lipid metabolizing enzyme family that utilizes oxygen and diiron-oxygen cofactor to hydroxylate, desaturate, epoxidate and acetylate substrates.
Literature References
PubMed ID Title Journal Year
9852097 cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

Kerr, TA, Russell, DW, Li, WP, Sakai, J, Lund, EG

J Biol Chem 1998
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as an event of
Catalyst Activity

steroid hydroxylase activity of CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane]

Physical Entity
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
steroid hydroxylase activity (GO:0008395)
Orthologous Events
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-19)
Reviewed
D'Eustachio, P  (2007-04-30)
Created
Jassal, B  (2007-01-26)
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