Reactome | Cholesterol is hydroxylated to 25-hydroxycholesterol

Cholesterol is hydroxylated to 25-hydroxycholesterol

Stable Identifier

R-HSA-191983

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

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Cholesterol is hydroxylated to 25-hydroxycholesterol

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The microsomal enzyme cholesterol 25-hydroxylase is a member of a lipid metabolizing enzyme family that utilizes oxygen and diiron-oxygen cofactor to hydroxylate, desaturate, epoxidate and acetylate substrates.

Literature References

PubMed ID	Title	Journal	Year
9852097	cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism Lund, EG, Kerr, TA, Sakai, J, Li, WP, Russell, DW	J Biol Chem	1998