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HMGCR-1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-191308
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase-1, HMDH_HUMAN, HMGCR isoform 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04035-1 HMGCR
Gene Names
HMGCR
Other Identifiers
0005900324
11727374_s_at
11727375_a_at
11727376_a_at
16986249
202539_s_at
202540_s_at
2815966
2815968
2815969
2815970
2815971
2815973
2815977
2815978
2815979
2815980
2815981
2815982
2815983
2815987
2815988
2815990
2815992
2815994
2815995
2815996
2815997
2816000
2816001
2816002
2816003
2816004
2816005
2816006
2816007
2816008
3156
39328_at
8106280
A_14_P201160
A_23_P30495
GE61694
GO:0003013
GO:0003674
GO:0004420
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005777
GO:0005778
GO:0005783
GO:0005789
GO:0006464
GO:0006629
GO:0006694
GO:0006695
GO:0006743
GO:0006810
GO:0006950
GO:0007165
GO:0007267
GO:0007568
GO:0007584
GO:0008150
GO:0008202
GO:0008203
GO:0008219
GO:0008283
GO:0008284
GO:0008299
GO:0008542
GO:0009056
GO:0009058
GO:0010664
GO:0010666
GO:0015031
GO:0015936
GO:0016020
GO:0016021
GO:0016126
GO:0016491
GO:0016616
GO:0019216
GO:0019899
GO:0030154
GO:0031667
GO:0032874
GO:0034641
GO:0038183
GO:0042177
GO:0042282
GO:0042592
GO:0042632
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0043407
GO:0044281
GO:0045445
GO:0045471
GO:0045540
GO:0048643
GO:0048661
GO:0048856
GO:0050661
GO:0050662
GO:0050709
GO:0050877
GO:0051186
GO:0051721
GO:0055114
GO:0061045
GO:0061179
GO:0070328
GO:0070374
GO:0070402
GO:0070723
GO:0097756
GO:0120225
GO:1900222
Hs.11899.0.S2_3p_a_at
M11058_at
PH_hs_0001121
TC05000363.hg
TC05002454.hg
g4557642_3p_a_at
Participant Of
output
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
hasMember
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane]
Inferred To
HMG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
hmgcra [endoplasmic reticulum membrane] (Danio rerio)
HMG2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
HMGCR [endoplasmic reticulum membrane] (Bos taurus)
HMGCR [endoplasmic reticulum membrane] (Canis familiaris)
HMGCR [endoplasmic reticulum membrane] (Gallus gallus)
Homologues of HMGCR-1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
Hmgcr [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hmgcr [endoplasmic reticulum membrane] (Mus musculus)
Hmgcr [endoplasmic reticulum membrane] (Rattus norvegicus)
hmg1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
hmgr-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
hmgA [endoplasmic reticulum membrane] (Dictyostelium discoideum)
hmgcr [endoplasmic reticulum membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001124468.1
,
XP_011541659.1
,
XP_011541660.1
,
NP_000850.1
ZINC - World Drugs
HMDH_HUMAN
OpenTargets
ENSG00000113161
ZINC - FDA approved
HMDH_HUMAN
ZINC - Substances
HMDH_HUMAN
ZINC target
P04035
ZINC - Biogenic
HMDH_HUMAN
PRO
P04035
PDB
3CCT
,
3CCZ
,
1HWJ
,
3CDA
,
1HW9
,
3CD7
,
3BGL
,
1DQ9
,
2Q6B
,
1DQA
,
3CCW
,
3CDB
,
1HWK
,
2Q6C
,
2R4F
,
1HWI
,
3CD5
,
1HW8
,
3CD0
,
2Q1L
,
1HWL
,
1DQ8
ZINC - Metabolites
HMDH_HUMAN
HPA
ENSG00000113161-HMGCR
GeneCards
P04035
Ensembl
ENSG00000113161
,
ENSP00000426745
,
ENST00000287936
,
ENST00000511206
,
ENST00000343975
,
ENSP00000340816
,
ENSP00000287936
ZINC - Predictions - Purchasable
HMDH_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.463
3
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