Reactome | HMGCR-1 [endoplasmic reticulum membrane]

HMGCR-1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-191308

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-hydroxy-3-methylglutaryl-coenzyme A reductase-1, HMDH_HUMAN, HMGCR isoform 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04035-1 HMGCR

Gene Names

HMGCR

Other Identifiers

0005900324

11727374_s_at

11727375_a_at

11727376_a_at

16986249

202539_s_at

202540_s_at

2815966

2815968

2815969

2815970

2815971

2815973

2815977

2815978

2815979

2815980

2815981

2815982

2815983

2815987

2815988

2815990

2815992

2815994

2815995

2815996

2815997

2816000

2816001

2816002

2816003

2816004

2816005

2816006

2816007

2816008

3156

39328_at

8106280

A_14_P201160

A_23_P30495

GE61694

GO:0003013

GO:0003674

GO:0004420

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005777

GO:0005778

GO:0005783

GO:0005789

GO:0006464

GO:0006629

GO:0006694

GO:0006695

GO:0006743

GO:0006810

GO:0006950

GO:0007165

GO:0007267

GO:0007568

GO:0007584

GO:0008150

GO:0008202

GO:0008203

GO:0008219

GO:0008283

GO:0008284

GO:0008299

GO:0008542

GO:0009056

GO:0009058

GO:0010664

GO:0010666

GO:0015031

GO:0015936

GO:0016020

GO:0016021

GO:0016126

GO:0016491

GO:0016616

GO:0019216

GO:0019899

GO:0030154

GO:0031667

GO:0032874

GO:0034641

GO:0038183

GO:0042177

GO:0042282

GO:0042592

GO:0042632

GO:0042802

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0043407

GO:0044281

GO:0045445

GO:0045471

GO:0045540

GO:0048643

GO:0048661

GO:0048856

GO:0050661

GO:0050662

GO:0050709

GO:0050877

GO:0051186

GO:0051721

GO:0055114

GO:0061045

GO:0061179

GO:0070328

GO:0070374

GO:0070402

GO:0070723

GO:0097756

GO:0120225

GO:1900222

Hs.11899.0.S2_3p_a_at

M11058_at

PH_hs_0001121

TC05000363.hg

TC05002454.hg

g4557642_3p_a_at

Participant Of

output

Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)

hasMember

Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane]

Inferred To

HMG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

hmgcra [endoplasmic reticulum membrane] (Danio rerio)

HMG2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

HMGCR [endoplasmic reticulum membrane] (Bos taurus)

HMGCR [endoplasmic reticulum membrane] (Canis familiaris)

HMGCR [endoplasmic reticulum membrane] (Gallus gallus)

Homologues of HMGCR-1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Hmgcr [endoplasmic reticulum membrane] (Drosophila melanogaster)

Hmgcr [endoplasmic reticulum membrane] (Mus musculus)

Hmgcr [endoplasmic reticulum membrane] (Rattus norvegicus)

hmg1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

hmgr-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hmgA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

hmgcr [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001124468.1, XP_011541659.1, XP_011541660.1, NP_000850.1

ZINC - World Drugs

HMDH_HUMAN

OpenTargets

ENSG00000113161

ZINC - FDA approved

HMDH_HUMAN

ZINC - Substances

HMDH_HUMAN

ZINC target

P04035

ZINC - Biogenic

HMDH_HUMAN

PRO

P04035

PDB

3CCT, 3CCZ, 1HWJ, 3CDA, 1HW9, 3CD7, 3BGL, 1DQ9, 2Q6B, 1DQA, 3CCW, 3CDB, 1HWK, 2Q6C, 2R4F, 1HWI, 3CD5, 1HW8, 3CD0, 2Q1L, 1HWL, 1DQ8

ZINC - Metabolites

HMDH_HUMAN

HPA

ENSG00000113161-HMGCR

GeneCards

P04035

Ensembl

ENSG00000113161, ENSP00000426745, ENST00000287936, ENST00000511206, ENST00000343975, ENSP00000340816, ENSP00000287936

ZINC - Predictions - Purchasable

HMDH_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.463	3