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HMGCR-1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-191308
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase-1, HMDH_HUMAN, HMGCR isoform 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCR dimer binds statins (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer:statins [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
HMGCR-1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04035-1 HMGCR
Gene Names
HMGCR
Other Identifiers
11727374_s_at
11727375_a_at
11727376_a_at
16986249
202539_PM_s_at
202539_s_at
202540_PM_s_at
202540_s_at
2815966
2815968
2815969
2815970
2815971
2815973
2815977
2815978
2815979
2815980
2815981
2815982
2815983
2815987
2815988
2815990
2815992
2815994
2815995
2815996
2815997
2816000
2816001
2816002
2816003
2816004
2816005
2816006
2816007
2816008
2816009
2816012
2816013
3156
39328_at
43868_at
8106280
A_14_P126678
A_14_P201160
A_23_P30495
GE61694
GO:0003824
GO:0004420
GO:0005515
GO:0005777
GO:0005778
GO:0005783
GO:0005789
GO:0006629
GO:0006694
GO:0006695
GO:0008202
GO:0008203
GO:0008299
GO:0008542
GO:0015936
GO:0016020
GO:0016126
GO:0016491
GO:0016616
GO:0023052
GO:0030163
GO:0030695
GO:0042177
GO:0043226
GO:0050661
GO:0050709
GO:0050877
GO:0055086
GO:0060291
GO:0070372
GO:0070402
GO:0098772
GO:0120225
GO:1900222
GO:1901135
HMNXSV003007418
Hs.11899.0.S2_3p_a_at
M11058_at
PH_hs_0001121
TC05000363.hg
TC05002453.hg
TC05002454.hg
g4557642_3p_a_at
p26865
Participates
as an output of
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
as a member of
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
HMGCR [endoplasmic reticulum membrane]
(Bos taurus)
HMGCR [endoplasmic reticulum membrane]
(Canis familiaris)
HMGCR [endoplasmic reticulum membrane]
(Sus scrofa)
Hmgcr [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Hmgcr [endoplasmic reticulum membrane]
(Mus musculus)
Hmgcr [endoplasmic reticulum membrane]
(Rattus norvegicus)
hmgcr1 [endoplasmic reticulum membrane]
(Danio rerio)
hmgr-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
HMGCR-1 [endoplasmic reticulum membrane]
(Gallus gallus)
HMGCR-1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
HMGCR-1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
hmgA [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
hmgcr [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011541660.1
,
NP_001124468.1
,
XP_011541659.1
,
NP_000850.1
ZINC - World Drugs
HMDH_HUMAN
Guide to Pharmacology - Targets
639
OpenTargets
ENSG00000113161
ZINC - FDA approved
HMDH_HUMAN
ZINC - Substances
HMDH_HUMAN
ZINC - Biogenic
HMDH_HUMAN
ZINC target
P04035
PRO
P04035
PDB
1HWK
,
3CCT
,
2Q6C
,
1DQA
,
3CD7
,
3BGL
,
1DQ9
,
3CD0
,
1HW8
,
3CDA
,
3CCW
,
2Q6B
,
2R4F
,
1HWJ
,
3CDB
,
1HWI
,
2Q1L
,
3CD5
,
3CCZ
,
1HWL
,
1HW9
,
1DQ8
ZINC - Metabolites
HMDH_HUMAN
HPA
ENSG00000113161-HMGCR
GeneCards
P04035
Ensembl
ENST00000681410
,
ENSP00000287936
,
ENST00000680940
,
ENST00000511206
,
ENST00000343975
,
ENSP00000506232
,
ENSP00000505561
,
ENSP00000505805
,
ENSP00000340816
,
ENST00000287936
,
ENST00000681271
,
ENSG00000113161
,
ENSP00000426745
Pharos - Targets
P04035
ZINC - Predictions - Purchasable
HMDH_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.463
3
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