Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)

Stable Identifier
R-HSA-1655826
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
8647822 A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

Rosenfeld, JM, Osborne, TF, Sanchez, HB, Vallett, SM

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MTF1 dimer:12Zn2+:HMGCR gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Regulator
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Kersten, S  (2009-06-08)
Created
May, B  (2011-10-13)
Cite Us!