MAML in complex with NICD1 recruits CDK8

Stable Identifier
R-HSA-1912393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MAML in complex with NICD1 recruits CDK8
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After NOTCH1 coactivator complex is assembled on a NOTCH-target promoter, MAML (mastermind-like) recruits CDK8 in complex with cyclin C (CDK:CCNC) (Fryer et al. 2004).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, Jones, KA, White, JB

Mol Cell 2004
Participants
Input
Output
Participates
as an event of
Inferred From
MAML recruits CDK8:CCNC to xNICD1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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