MAML recruits CDK8:CCNC to xNICD1

Stable Identifier
R-NUL-2064916
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
MAML recruits CDK8:CCNC to xNICD1

Recruitment of CDK8 and cyclin C (CDK8:CCNC) by MAML, a constituent of the NOTCH1 coactivator complex, was studied in HeLa cells in which tagged human MAML, CDK8 and CCNC proteins were expressed together with a tagged Xenopus NICD1 (xNICD1).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Orthologous Events
Authored
Reviewed
Created
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