Reactome | maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)

maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)

Stable Identifier

R-HSA-191116

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose

ReviewStatus

5/5

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maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)

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Maltotriose is representative of linear glucose oligomers containing more than two residues. The 1-4 linkages of extracellular maltotriose are hydrolyzed to yield maltose and glucose in a reaction catalyzed by the exoglucosidase activity of maltase-glucoamylase (Nichols et al. 1998). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on maltotriose derived directly from the diet and from the hydrolysis of starch. This reaction can also be catalyzed by sucrase-isomaltase, but maltase-glucoamylase is about a hundredfold more active.

Literature References

PubMed ID	Title	Journal	Year
3897250	Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells Hauri, HP, Sterchi, EE, Bienz, D, Fransen, JA, Marxer, A	J Cell Biol	1985
12547908	The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities Nichols, BL, Avery, S, Sen, P, Swallow, DM, Hahn, D, Sterchi, EE	Proc Natl Acad Sci U S A	2003