maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)

Stable Identifier
Reaction [transition]
Homo sapiens
Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
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Maltotriose is representative of linear glucose oligomers containing more than two residues. The 1-4 linkages of extracellular maltotriose are hydrolyzed to yield maltose and glucose in a reaction catalyzed by the exoglucosidase activity of maltase-glucoamylase (Nichols et al. 1998). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on maltotriose derived directly from the diet and from the hydrolysis of starch. This reaction can also be catalyzed by sucrase-isomaltase, but maltase-glucoamylase is about a hundredfold more active.

Literature References
PubMed ID Title Journal Year
3897250 Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells

Hauri, HP, Fransen, JA, Bienz, D, Marxer, A, Sterchi, EE

J Cell Biol 1985
12547908 The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities

Swallow, DM, Sterchi, EE, Hahn, D, Sen, P, Nichols, BL, Avery, S

Proc Natl Acad Sci U S A 2003
Catalyst Activity

alpha-1,4-glucosidase activity of MGAM dimer [plasma membrane]

Orthologous Events
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