Reactome | FGFR1c binds to Klotho-bound FGF23

FGFR1c binds to Klotho-bound FGF23

Stable Identifier

R-HSA-190268

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - FGFR1 ligand binding and activation (Homo sapiens)
        
        FGFR1c and Klotho ligand binding and activation (Homo sapiens)
        
        FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)

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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Also, TGFBR3 (beta-glycan) facilitates the binding of FGF2 with its receptor FGFR1 by binding with FGF2 itself and bringing more ligands into receptor proximity (Andres et al. 1992, Knelson et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
16597617	Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X	J Biol Chem	2006
17086194	Klotho converts canonical FGF receptor into a specific receptor for FGF23 Yamazaki, Y, Fukumoto, S, Shimada, T, Iijima, K, Urakawa, I, Okawa, K, Fujita, T, Yameshita, T, Hasegawa, H	Nature	2006