FGFR1c binds to Klotho-bound FGF23

Stable Identifier
R-HSA-190268
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate.

Literature References
PubMed ID Title Journal Year
17086194 Klotho converts canonical FGF receptor into a specific receptor for FGF23

Fujita, T, Fukumoto, S, Hasegawa, H, Iijima, K, Okawa, K, Shimada, T, Urakawa, I, Yamazaki, Y, Yameshita, T

Nature 2006
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Zhang, X, Ibrahimi, OA, Olsen, SK, Umemori, H, Mohammadi, M, Ornitz, DM

J Biol Chem 2006
Participants
Participant Of
This event is regulated
Orthologous Events
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