FGFR1c binds to Klotho-bound FGF23

Stable Identifier
R-HSA-190268
Type
Reaction
Species
Homo sapiens
Compartment
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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate.

Literature References
PubMed ID Title Journal Year
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X

J Biol Chem 2006
17086194 Klotho converts canonical FGF receptor into a specific receptor for FGF23

Yamazaki, Y, Fukumoto, S, Shimada, T, Iijima, K, Urakawa, I, Okawa, K, Fujita, T, Yameshita, T, Hasegawa, H

Nature 2006
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