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FGF23 bound to Klotho and FGFR1c [plasma membrane]
Stable Identifier
R-HSA-190218
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1c and Klotho ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Participants
components
FGFR1c homodimer [plasma membrane]
(Homo sapiens)
HS [extracellular region]
x 2
Klotho bound to FGF23 [plasma membrane]
(Homo sapiens)
Participates
as an output of
FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
as an input of
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
Inferred To
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Bos taurus)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Caenorhabditis elegans)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Canis familiaris)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Danio rerio)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Drosophila melanogaster)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Gallus gallus)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Mus musculus)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Rattus norvegicus)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Sus scrofa)
FGF23 bound to Klotho and FGFR1c [plasma membrane]
(Xenopus tropicalis)
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