sucrose + H2O => glucose + fructose

Stable Identifier
R-HSA-189069
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Digestion of sucrose to yield glucose and fructose
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Extracellular sucrose is hydrolyzed to yield glucose and fructose in a reaction catalyzed by the sucrase domain of sucrase-isomaltase (Conklin et al. 1975). In the body, this enzyme is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). The sucrase-isomaltase polypeptide is cleaved into its sucrase and isomaltase domains, which remain associated and, by analogy to the corresponding pig enzyme, are thought to dimerize (Cowell et al. 1986).

Literature References
PubMed ID Title Journal Year
807575 Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits.

Conklin, KA, Yamashiro, KM, Gray, GM

J Biol Chem 1975
3897250 Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells

Hauri, HP, Sterchi, EE, Bienz, D, Fransen, JA, Marxer, A

J Cell Biol 1985
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sucrose alpha-glucosidase activity of sucrase-isomaltase dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
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