Reactome | sucrose + H2O => glucose + fructose

sucrose + H2O => glucose + fructose

Stable Identifier

R-HSA-189069

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Digestion of sucrose to yield glucose and fructose

ReviewStatus

5/5

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Extracellular sucrose is hydrolyzed to yield glucose and fructose in a reaction catalyzed by the sucrase domain of sucrase-isomaltase (Conklin et al. 1975). In the body, this enzyme is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). The sucrase-isomaltase polypeptide is cleaved into its sucrase and isomaltase domains, which remain associated and, by analogy to the corresponding pig enzyme, are thought to dimerize (Cowell et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3897250	Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells Hauri, HP, Fransen, JA, Bienz, D, Marxer, A, Sterchi, EE	J Cell Biol	1985
807575	Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits. Gray, GM, Conklin, KA, Yamashiro, KM	J Biol Chem	1975