Extracellular sucrose is hydrolyzed to yield glucose and fructose in a reaction catalyzed by the sucrase domain of sucrase-isomaltase (Conklin et al. 1975). In the body, this enzyme is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). The sucrase-isomaltase polypeptide is cleaved into its sucrase and isomaltase domains, which remain associated and, by analogy to the corresponding pig enzyme, are thought to dimerize (Cowell et al. 1986).
Hauri, HP, Fransen, JA, Bienz, D, Marxer, A, Sterchi, EE
Gray, GM, Conklin, KA, Yamashiro, KM
sucrose alpha-glucosidase activity of sucrase-isomaltase dimer [plasma membrane]
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