Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose

Stable Identifier
R-HSA-189053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose
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The 1-6 linkages in extracellular limit dextrins are hydrolyzed by sucrase-isomaltase to yield maltose, maltotriose, longer maltosides, and glucose (Conklin et al. 1975; Nichols et al. 1998). In the body, this enzyme is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on limit dextrins generated by the hydrolysis of amylopectin starch.
Literature References
PubMed ID Title Journal Year
3897250 Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells

Hauri, HP, Sterchi, EE, Bienz, D, Fransen, JA, Marxer, A

J Cell Biol 1985
9446624 Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase.

Nichols, BL, Eldering, J, Avery, S, Hahn, D, Quaroni, A

J Biol Chem 1998
807575 Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits.

Conklin, KA, Yamashiro, KM, Gray, GM

J Biol Chem 1975
Participants
Input
Output
Participates
as an event of
Catalyst Activity

alpha-1,4-glucosidase activity of sucrase-isomaltase dimer [plasma membrane]

Physical Entity
sucrase-isomaltase dimer [plasma membrane] (Homo sapiens)
Activity
alpha-1,4-glucosidase activity (GO:0004558)
Orthologous Events
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Canis familiaris)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Dictyostelium discoideum)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Mus musculus)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Sus scrofa)
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Xenopus tropicalis)
Authored
D'Eustachio, P  (2006-11-03)
Reviewed
Nichols, BL  (2007-01-16)
Created
D'Eustachio, P  (2006-11-03)
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