Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Stable Identifier

R-HSA-174178

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

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From late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Geminin (see Castro et al., 2005). Rape et al. have recently demonstrated that the order in which APC/C targeted proteins are degraded is determined by the processivity of multiubiquitination of these substrates. Processive substrates acquire a polyubiquitin chain upon binding to the APC/C once and are degraded. Distributive substrates bind, dissociate and reassociate with the APC/C multiple times before acquiring an ubiquitin chain of sufficient length to insure degradation. In addition, distributive substrates that dissociate from the APC/C with short ubiquitin chains are targeted for deubiquitination (Rape et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
15678131	The anaphase-promoting complex: a key factor in the regulation of cell cycle Lorca, T, Bernis, C, Vigneron, S, Castro, A, Labbe, JC	Oncogene	2005
16413484	The processivity of multiubiquitination by the APC determines the order of substrate degradation Kirschner, MW, Rape, M, Reddy, SK	Cell	2006