Synthesis of IPs in the nucleus

Stable Identifier
R-HSA-1855191
Type
Pathway
Species
Homo sapiens
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Within the nucleus, inositol polyphosphate multikinase (IPMK), inositol-pentakisphosphate 2-kinase (IPPK), inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) produce IP5, IP6, IP7, and IP8 inositol phosphate molecules (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Nalaskowski et al. 2002, Chang et al. 2002, Chang & Majerus 2006, Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008, Mulugu et al. 2007).

Literature References
PubMed ID Title Journal Year
10827188 The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis

Saiardi, A, Caffrey, JJ, Snyder, SH, Shears, SB

J Biol Chem 2000
20359876 Inositol phosphate synthesis and the nuclear processes they affect

Monserrate, JP, York, JD

Curr Opin Cell Biol 2010
17943301 Inositol polyphosphates: a new frontier for regulating gene expression

Alcázar-Román, AR, Wente, SR

Chromosoma 2008
16293229 Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

Chang, SC, Majerus, PW

Biochem Biophys Res Commun 2006
11331907 Back in the water: the return of the inositol phosphates

Irvine, RF, Schell, MJ

Nat Rev Mol Cell Biol 2001
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M

Chem Biol 2008
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH

J Biol Chem 2001
16781889 Regulation of nuclear processes by inositol polyphosphates

York, JD

Biochim Biophys Acta 2006
12223481 The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

Chang, SC, Miller, AL, Feng, Y, Wente, SR, Majerus, PW

J Biol Chem 2002
12027805 The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

Nalaskowski, MM, Deschermeier, C, Fanick, W, Mayr, GW

Biochem J 2002
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD

Science 2007
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