Activated FGFR1 phosphorylates PLCG1

Stable Identifier
R-HSA-5654149
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PLC gamma is phosphorylated by activated FGFR, resulting in PLC gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3. Tyrosine phosphorylation of PLCgamma by FGFR4 is weaker than that seen by other isoforms of FGFR.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of activated FGFR1:PLCG1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created