Norepinephrine Neurotransmitter Release Cycle

Stable Identifier
Homo sapiens
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Noradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, conversion of dopamine into Noradrenalin, docking and priming of the noradrenalin synaptic veiscle and then release of noradrenalin synaptic vesicle. In the peripheral nervous system in the peripheral nervous system noradrenalin is stored in large and small dense vesicles and is realesed from large vesicles.

Literature References
PubMed ID Title Journal Year
17478680 How synaptotagmin promotes membrane fusion

Martens, S, Kozlov, MM, McMahon, HT

Science 2007
12519779 Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis

Barclay, JW, Craig, TJ, Fisher, RJ, Ciufo, LF, Evans, GJ, Morgan, A, Burgoyne, RD

J Biol Chem 2003
17891149 Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

Stein, A, Radhakrishnan, A, Riedel, D, Fasshauer, D, Jahn, R

Nat Struct Mol Biol 2007
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