Catabolism of Noradrenaline

Stable Identifier
R-HSA-374909
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Catabolism of Noradrenaline
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Noradrenaline is degraded by Monoamine oxidase A, which contains FAD as a cofactor. Monoamine oxidase is located in the outer mitochondrial membrane facing the cytoplasm. Monoamine oxidase functions as a monomer and is functional both is astrocyes and neurons.
Literature References
PubMed ID Title Journal Year
8211186 Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

Brunner, HG, Nelen, M, Breakefield, XO, Ropers, HH, van Oost, BA

Science 1993
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Input
Output
Participates
as an event of
Event Information
Go Biological Process
norepinephrine catabolic process (0042422)
Catalyst Activity

primary methylamine oxidase activity of MAOA:FAD [mitochondrial outer membrane]

Physical Entity
MAOA:FAD [mitochondrial outer membrane] (Homo sapiens)
Activity
primary methylamine oxidase activity (GO:0008131)
Orthologous Events
Catabolism of Noradrenaline (Bos taurus)
Catabolism of Noradrenaline (Canis familiaris)
Catabolism of Noradrenaline (Danio rerio)
Catabolism of Noradrenaline (Dictyostelium discoideum)
Catabolism of Noradrenaline (Gallus gallus)
Catabolism of Noradrenaline (Mus musculus)
Catabolism of Noradrenaline (Rattus norvegicus)
Catabolism of Noradrenaline (Sus scrofa)
Catabolism of Noradrenaline (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-06-26)
Created
Mahajan, SS  (2008-08-06)
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