Metabolism of Noradrenaline

Stable Identifier
R-HSA-374909
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
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Metabolism of Noradrenaline
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Noradrenaline is degraded by Monoamine oxidase A, which contains FAD as a cofactor. Monoamine oxidase is located in the outer mitochondrial membrane facing the cytoplasmic site. Monoamine xoidase functions as a monomer and is functional both is astrocyes and neurons.

Literature References
PubMed ID Title Journal Year
8211186 Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

Brunner, HG, Nelen, M, Breakefield, XO, Ropers, HH, van Oost, BA

Science 1993
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
neurotransmitter metabolic process (0042133)
Catalyst Activity
Catalyst Activity
Title
primary amine oxidase activity of MAOA:FAD [mitochondrial outer membrane]
Physical Entity
MAOA:FAD [mitochondrial outer membrane]
Activity
primary amine oxidase activity (0008131)
Orthologous Events
Metabolism of Noradrenaline (Bos taurus)
Metabolism of Noradrenaline (Canis familiaris)
Metabolism of Noradrenaline (Dictyostelium discoideum)
Metabolism of Noradrenaline (Drosophila melanogaster)
Metabolism of Noradrenaline (Gallus gallus)
Metabolism of Noradrenaline (Mus musculus)
Metabolism of Noradrenaline (Rattus norvegicus)
Authored
Mahajan, SS  (2008-06-26)
Created
Mahajan, SS  (2008-08-06)
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