DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function

Stable Identifier
R-HSA-180038
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function
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DARPP-32 is phosphorylated by cAMP-dependent protein kinase (PKA) on a single threonine residue, Thr34, resulting in its conversion into a potent inhibitor of protein phosphatase-1.
Literature References
PubMed ID Title Journal Year
6087160 DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

Hemmings HC, Jr, Greengard, P, Tung, HY, Cohen, P

Nature 1984
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Catalyst Activity

protein phosphatase regulator activity of Phosphorylated (T34) DARPP-32:PP1A [cytosol]

Physical Entity
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Homo sapiens)
Activity
protein phosphatase regulator activity (GO:0019888)
Orthologous Events
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Gallus gallus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Xenopus tropicalis)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-05-16)
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