Reactome | SMAD7:SMURF complex binds to phosphorylated TGFBR1

SMAD7:SMURF complex binds to phosphorylated TGFBR1

Stable Identifier

R-HSA-178218

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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SMAD7:SMURF complex binds to phosphorylated TGFBR1

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SMAD7 binds to phosphorylated TGFBR1 (TGF-beta receptor I), thereby recruiting SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) ubiquitin ligases to the activated TGF-beta receptor complex. This is based on experiments in which recombinant mouse Smad7 was used together with recombinant human ubiquitin ligases and TGF-beta receptors.

Literature References

PubMed ID	Title	Journal	Year
15496141	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Kuratomi, G, Komuro, A, Goto, K, Shinozaki, M, Miyazawa, K, Miyazono, K, Imamura, T	Biochem J	2005
11278251	Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K	J Biol Chem	2001
11163210	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL	Mol Cell	2000