Smad7:SMURF2 binds phosphorylated TGFBR1

Stable Identifier
R-NUL-2169043
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Smad7:SMURF2 binds phosphorylated TGFBR1

Smad7 recruits SMURF2 to TGF-beta (TGFB1)-activated TGF-beta receptor complex. In this study, recombinant mouse Smad7 and recombinant human SMURF2, TGFBR2 and TGFBR1 were exogenously expressed in COS1 cells (Kavsak et al. 2000).

Literature References
PubMed ID Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL

Mol Cell 2000
Participants
Orthologous Events
Authored
Reviewed
Created
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