SHC1 events in EGFR signaling

Stable Identifier
R-HSA-180336
DOI
10.3180/REACT_12579.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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SHC1 events in EGFR signaling
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GRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
Literature References
PubMed ID Title Journal Year
11498013 Internalization of the epidermal growth factor receptor: role in signalling

Sorkin, A

Biochem Soc Trans 2001
8755247 Not all Shc's roads lead to Ras

Pelicci, G, Bonfini, L, Migliaccio, E, Lanfrancone, L, Pelicci, PG

Trends Biochem Sci 1996
Participants
Events
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Orthologous Events
SHC1 events in EGFR signaling (Bos taurus)
SHC1 events in EGFR signaling (Caenorhabditis elegans)
SHC1 events in EGFR signaling (Canis familiaris)
SHC1 events in EGFR signaling (Danio rerio)
SHC1 events in EGFR signaling (Drosophila melanogaster)
SHC1 events in EGFR signaling (Gallus gallus)
SHC1 events in EGFR signaling (Mus musculus)
SHC1 events in EGFR signaling (Rattus norvegicus)
SHC1 events in EGFR signaling (Sus scrofa)
SHC1 events in EGFR signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-05-18)
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