Conjugation of benzoate with glycine

Stable Identifier
R-HSA-177135
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Conjugation of benzoate with glycine
Click the image above or here to open this pathway in the Pathway Browser
Benzoic acid, widely used as a food preservative, is converted to hippuric acid by activation and conjugation with glycine. This was one of the first detoxification pathways discovered, and was formerly exploited clinically as an alternative means of nitrogen excretion in patients with urea cycle defects (Brusilow and Horwich 2001).
Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Scriver, CR, Beaudet, AL, Valle, D, Sly, WS

  2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
xenobiotic metabolic process (0006805)
Orthologous Events
Conjugation of benzoate with glycine (Bos taurus)
Conjugation of benzoate with glycine (Caenorhabditis elegans)
Conjugation of benzoate with glycine (Canis familiaris)
Conjugation of benzoate with glycine (Danio rerio)
Conjugation of benzoate with glycine (Gallus gallus)
Conjugation of benzoate with glycine (Mus musculus)
Conjugation of benzoate with glycine (Rattus norvegicus)
Conjugation of benzoate with glycine (Sus scrofa)
Conjugation of benzoate with glycine (Xenopus tropicalis)
Authored
Jassal, B  (2004-11-30)
Created
D'Eustachio, P  (2006-03-24)
Cite Us!