Reactome | benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Stable Identifier

R-HSA-159443

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Benzoate and Coenzyme A react to form benzoyl-CoA thioester

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Amino Acid conjugation (Homo sapiens)
      - Conjugation of carboxylic acids (Homo sapiens)
        
        Conjugation of benzoate with glycine (Homo sapiens)
        
        benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)

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benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

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Benzoate and ATP react with coenzyme A to form benzoyl CoA, AMP, and pyrophosphate (Vessey et al. 1999, 2003). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to benzoate metabolism in vivo are unknown.

Literature References

PubMed ID	Title	Journal	Year
12616642	Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria Kelley, M, Warren, RS, Lau, E, Vessey, DA	J Biochem Mol Toxicol	2003
10434065	Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids Kelley, M, Warren, RS, Vessey, DA	Biochim Biophys Acta	1999