Reactome | LPA [extracellular region]

LPA [extracellular region]

Stable Identifier

R-HSA-176877

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

apolipoprotein(a), apo(a)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08519 LPA

Gene Names

LPA

Chain

signal peptide:1-19, chain:20-4548

Reference Genes

COSMIC (genes):LPA LPA

ENSEMBL:ENSG00000198670 LPA

HGNC:6667 LPA

OMIM:152200 LPA

UCSC:P08519 LPA

Other Identifiers

0006550095

11740823_s_at

11746858_a_at

11746859_a_at

17025359

207584_at

209978_s_at

2492661

2498398

2563067

2934685

2934710

2934721

2934730

2982637

2982639

2982643

2982647

2982648

2982649

2982651

2982652

2982654

2982662

2982669

2982677

2982684

2982686

2982692

2982731

2982732

2982733

2982734

2982737

2982738

2982739

2982741

2982742

2982743

2982744

2982746

2982747

2982748

2982750

2982751

2982752

2982753

2982754

2982755

2982756

2982757

2982758

2982759

2982760

2982761

2982762

2982763

2982764

2982766

2982767

2982768

2982769

2982770

2982771

2982772

2982773

2982775

2982777

2982779

2982781

2982783

2982786

2982787

2982788

2982800

2982802

2982804

2982806

2982808

2982810

2982812

2982816

2982818

2982820

2982822

2982828

2982830

2982833

2982835

2982837

2982839

2982841

2982847

2982849

2982851

2982855

2982857

2982859

2982875

2982877

2982879

31721_at

4018

8130608

A_23_P95221

A_24_P41801

GE59680

GO:0001968

GO:0003013

GO:0003674

GO:0004252

GO:0004866

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006508

GO:0006629

GO:0006810

GO:0006869

GO:0008015

GO:0008150

GO:0008201

GO:0008233

GO:0008236

GO:0010951

GO:0016787

GO:0030234

GO:0032991

GO:0034185

GO:0034358

GO:0034374

GO:0043167

ILMN_1731670

ILMN_2260643

ILMN_2346987

ILMN_3301551

PH_hs_0028627

TC06002281.hg

X06290_at

g5031884_3p_at

Participant Of

hasComponent

Lp(a) [extracellular region]

input

apolipoprotein(a) + LDL => Lp(a)

Inferred To

plg [extracellular region] (Danio rerio)

LPA [extracellular region] (Xenopus tropicalis)

Plg [extracellular region] (Mus musculus)

Plg [extracellular region] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000198670

HPA

ENSG00000198670-LPA

GeneCards

P08519

Ensembl

ENSG00000198670, ENSP00000395608, ENST00000447678, ENSP00000321334, ENST00000316300

PRO

P08519

Orphanet

24680

PDB

1JFN, 4KIV, 4BVW, 4BV5, 4BVD, 4BV7, 1KIV, 1I71, 6RX7, 3KIV, 4BVC, 4BVV, 2FEB

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02749 APOH	2	APOH [platelet dense granule lumen] (R-HSA-8848901) APOH [extracellular region] (R-HSA-8848905)	0.593	4
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.592	2