Reactome | C8A [extracellular region]

C8A [extracellular region]

Stable Identifier

R-HSA-173716

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C8 Alpha

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07357 C8A

Gene Names

C8A

Chain

signal peptide:1-20, propeptide:21-30, chain:31-584

Reference Genes

BioGPS Gene:731 C8A

COSMIC (genes):C8A C8A

CTD Gene:731 C8A

dbSNP Gene:731 C8A

ENSEMBL:ENSG00000157131 C8A

HGNC:1352 C8A

KEGG:hsa:731 C8A

Monarch:731 C8A

NCBI Gene:731 C8A

OMIM:120950 C8A

UCSC:P07357 C8A

Reference Transcript

RefSeq:NM_000562.2 C8A

Other Identifiers

11743199_at

16665193

206305_PM_s_at

206305_s_at

2337789

2337790

2337791

2337792

2337794

2337795

2337796

2337797

2337798

2337799

2337801

2337802

2337804

2337807

2337808

2337809

2337810

2337812

2337813

2337814

2337815

2337816

2337817

2337818

2337819

2337820

2337821

2337822

41023_at

63265_at

731

7901732

A_14_P102097

A_14_P137374

A_23_P46639

GE545521

GE57850

GO:0001848

GO:0002376

GO:0005515

GO:0005576

GO:0005579

GO:0005615

GO:0005886

GO:0006955

GO:0006956

GO:0006957

GO:0006958

GO:0016020

GO:0031640

GO:0043226

GO:0044877

GO:0045087

GO:0050778

GO:0070062

GO:0072562

GO:0098542

HMNXSV003028893

ILMN_1710606

PH_hs_0005133

TC01000686.hg

U08006_s_at

g4557388_3p_a_at

Participates

as a component of

C8 [extracellular region] (Homo sapiens)

Inferred To

C8A [extracellular region] (Bos taurus)

C8A [extracellular region] (Canis familiaris)

C8A [extracellular region] (Gallus gallus)

C8A [extracellular region] (Sus scrofa)

C8a [extracellular region] (Mus musculus)

Cross References

ENSEMBL

ENSG00000157131, ENSP00000354458, ENST00000361249

OpenTargets

ENSG00000157131

GeneCards

C8A

HPA

ENSG00000157131-C8A

PRO

P07357

Pharos - Targets

P07357

Orphanet

C8A

PDB

8B0F, 2RD7, 6H04, 2QQH, 7NYD, 8B0G, 3OJY, 7NYC, 2QOS, 8B0H, 6H03

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:P01031 C5	7	C5a [extracellular region] (R-HSA-173677) C5 beta chain [extracellular region] (R-HSA-173675) C5 alpha chain [extracellular region] (R-HSA-173673) C5b alpha' [extracellular region] (R-HSA-173672) C5a-desArg [extracellular region] (R-HSA-8852798) C5aT [extracellular region] (R-HSA-8852711) C5(965-1676) [extracellular region] (R-HSA-8852713)	0.553	2