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Go!
C8 [extracellular region]
Stable Identifier
R-HSA-173713
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
CD59 inhibits MAC formation (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
CD59:C5b-C9 [plasma membrane] (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
Formation of soluble VTN:C5b-C9 (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7:C8:C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C7 binds C5b:C6 (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8 binds C5b:C6:C7 (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C9 binds C5b:C6:C7:C8 (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
Membrane Attack Complex [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12463754
Binding of human complement C8 to C9: role of the N-terminal modules in the C8 alpha subunit
Plumb, ME
,
Scibek, JJ
,
Sodetz, JM
Biochemistry
2002
Participants
components
C8A [extracellular region]
(Homo sapiens)
C8B [extracellular region]
(Homo sapiens)
C8G [extracellular region]
(Homo sapiens)
Participates
as a component of
Membrane Attack Complex [plasma membrane] (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
VTN:C5b:C6:C7:C8:C9 [extracellular region] (Homo sapiens)
as an input of
C8 binds C5b:C6:C7 (Homo sapiens)
Formation of soluble VTN:C5b-C9 (Homo sapiens)
as a member of
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
Inferred To
C8 [extracellular region]
(Bos taurus)
C8 [extracellular region]
(Canis familiaris)
C8 [extracellular region]
(Gallus gallus)
C8 [extracellular region]
(Mus musculus)
C8 [extracellular region]
(Sus scrofa)
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