Reactome | GCKR [cytosol]

GCKR [cytosol]

Stable Identifier

R-HSA-170818

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GKRP, glucokinase regulatory protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14397 GCKR

Gene Names

GCKR

Chain

chain:1-625

Reference Genes

BioGPS Gene:2646 GCKR

COSMIC (genes):GCKR GCKR

CTD Gene:2646 GCKR

dbSNP Gene:2646 GCKR

ENSEMBL:ENSG00000084734 GCKR

HGNC:4196 GCKR

KEGG:hsa:2646 GCKR

Monarch:2646 GCKR

NCBI Gene:2646 GCKR

OMIM:600842 GCKR

UCSC:Q14397 GCKR

Reference Transcript

RefSeq:NM_001486.3 GCKR

Participates

as an input of

glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)

as an output of

cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)

as a component of

GCK1:GCKR complex [cytosol] (Homo sapiens)

Other forms of this molecule

GCKR [nucleoplasm]

Inferred To

gckr [cytosol] (Xenopus tropicalis)

GCKR [cytosol] (Canis familiaris)

Gckr [cytosol] (Mus musculus)

Gckr [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001477.2

OpenTargets

ENSG00000084734

GeneCards

GCKR

ZINC - Substances

GCKR_HUMAN

ZINC target

Q14397

PRO

Q14397

Pharos - Targets

Q14397

ZINC - Predictions - Purchasable

GCKR_HUMAN

HMDB Protein

HMDBP02909

PDB

4LY9, 4BBA, 4PX5, 4MRO, 4MSU, 4OHO, 4OHP, 4BB9, 4OHM, 4OP1, 4PX2, 4PX3, 4OP2, 4OLH, 4MQU, 4OHK, 4PXS, 4OP3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35557 GCK	8	GCK [cytosol] (R-HSA-450094) GCK [nucleoplasm] (R-HSA-450102) GCK G229R [cytosol] (R-HSA-5621863) GCK T228M [cytosol] (R-HSA-5621852) GCK E279* [cytosol] (R-HSA-5621903) GCK E339K [cytosol] (R-HSA-5621913) GCK G261R [cytosol] (R-HSA-5621848) GCK A378T [cytosol] (R-HSA-5621850)	0.719	5

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