cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

Stable Identifier
R-HSA-170799
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The cytosolic glucokinase (GCK1):glucokinase regulatory protein (GKRP) complex dissociates.However, while GCK1:GKRP complex formation is reversible (Brocklehurst et al. 2004) the major fate of these complexes in vivo appears to be transport to the nucleus (Shiota et al. 1999).

Literature References
PubMed ID Title Journal Year
14627435 Differences in regulatory properties between human and rat glucokinase regulatory protein

Brocklehurst, KJ, Davies, RA, Agius, L

Biochem J 2004
10601273 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA

J Biol Chem 1999
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Orthologous Events
Created