Reactome | cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

Stable Identifier

R-HSA-170799

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

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The cytosolic glucokinase (GCK1):glucokinase regulatory protein (GKRP) complex dissociates.However, while GCK1:GKRP complex formation is reversible (Brocklehurst et al. 2004) the major fate of these complexes in vivo appears to be transport to the nucleus (Shiota et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10601273	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase Magnuson, MA, Grimsby, J, Shiota, C, Coffey, J, Grippo, JF	J Biol Chem	1999
14627435	Differences in regulatory properties between human and rat glucokinase regulatory protein Brocklehurst, KJ, Agius, L, Davies, RA	Biochem J	2004