glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex

Stable Identifier
R-HSA-170824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
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Glucokinase (GCK1) reversibly binds glucokinase regulatory protein (GKRP) to form an inactive complex. Binding is stimulated by fructose 6-phosphate and sorbitol 6-phosphate (hence high concentrations of these molecules tend to reduce GCK1 activity) and inhibited by fructose 1-phosphate (hence a high concentration of this molecule tends to increase GCK1 activity) (Brocklehurst et al. 2004).

Literature References
PubMed ID Title Journal Year
14627435 Differences in regulatory properties between human and rat glucokinase regulatory protein

Brocklehurst, KJ, Davies, RA, Agius, L

Biochem J 2004
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Participant Of
hasEvent
Event Information
Reverse Reaction
cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)
This event is regulated
Negatively by
Positively by
Orthologous Events
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)
Created
D'Eustachio, P  (2006-01-17)
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