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glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
Stable Identifier
R-HSA-170824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)
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Glucokinase (GCK1) reversibly binds glucokinase regulatory protein (GKRP) to form an inactive complex. Binding is stimulated by fructose 6-phosphate and sorbitol 6-phosphate (hence high concentrations of these molecules tend to reduce GCK1 activity) and inhibited by fructose 1-phosphate (hence a high concentration of this molecule tends to increase GCK1 activity) (Brocklehurst et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
14627435
Differences in regulatory properties between human and rat glucokinase regulatory protein
Brocklehurst, KJ
,
Agius, L
,
Davies, RA
Biochem J
2004
Participants
Input
GCK [cytosol]
(Homo sapiens)
GCKR [cytosol]
(Homo sapiens)
Output
GCK1:GKRP complex [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens)
This event is regulated
Negatively by
Regulator
Fru 1-P [cytosol]
Positively by
Regulator
Sor6P [cytosol]
Regulator
Fru(6)P [cytosol]
Orthologous Events
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Canis familiaris)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)
Created
D'Eustachio, P (2006-01-17)
© 2025
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