glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Glucokinase (GCK1) reversibly binds glucokinase regulatory protein (GKRP) to form an inactive complex. Binding is stimulated by fructose 6-phosphate and sorbitol 6-phosphate (hence high concentrations of these molecules tend to reduce GCK1 activity) and inhibited by fructose 1-phosphate (hence a high concentration of this molecule tends to increase GCK1 activity) (Brocklehurst et al. 2004).

Literature References
PubMed ID Title Journal Year
14627435 Differences in regulatory properties between human and rat glucokinase regulatory protein

Brocklehurst, KJ, Davies, RA, Agius, L

Biochem J 2004
Participant Of
Event Information
This event is regulated
Negatively by
Orthologous Events
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