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SHC2 [cytosol]
Stable Identifier
R-HSA-167050
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC transforming protein 2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
SHC binds to the activated TrkA receptor (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98077 SHC2
Gene Names
SHC2, SCK, SHCB
Chain
chain:1-582
Reference Genes
BioGPS Gene:25759 SHC2
COSMIC (genes):SHC2 SHC2
CTD Gene:25759 SHC2
dbSNP Gene:25759 SHC2
ENSEMBL:ENSG00000129946 SHC2
ENSEMBL_homo_sapiens_GENE:ENSG00000129946.11 SHC2
HGNC:29869 SHC2
KEGG Gene (Homo sapiens):25759 SHC2
Monarch:25759 SHC2
NCBI Gene:25759 SHC2
OMIM:605217 SHC2
UCSC:P98077 SHC2
Reference Transcript
RefSeq:NM_012435.2 SHC2
Other Identifiers
11728145_a_at
16866435
213464_PM_at
213464_at
25759
35622_at
3844568
3844569
3844572
3844576
3844580
3844581
3844582
3844583
3844585
3844586
3844587
3844589
3844600
3844601
3844602
8032037
A_32_P205624
GE53025
GO:0005515
GO:0005575
GO:0005829
GO:0005886
GO:0007169
GO:0023052
GO:0030971
GO:0035556
HMNXSV003041270
Hs.30965.0.A1_3p_at
ILMN_1683857
ILMN_1721087
ILMN_1734667
RNA94954|RNS_36_198
TC19000985.hg
Participates
as a component of
VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane] (Homo sapiens)
as an input of
p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)
as a member of
SHC [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y-SHC2 [cytosol]
Inferred To
Shc2 [cytosol]
(Mus musculus)
Shc2 [cytosol]
(Rattus norvegicus)
Shc [cytosol]
(Drosophila melanogaster)
SHC2 [cytosol]
(Bos taurus)
SHC2 [cytosol]
(Canis familiaris)
SHC2 [cytosol]
(Gallus gallus)
SHC2 [cytosol]
(Sus scrofa)
shc2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_036567.2
OpenTargets
ENSG00000129946
HPA
ENSG00000129946-SHC2
GeneCards
P98077
ZINC target
P98077
Ensembl
ENSG00000129946
,
ENST00000264554
,
ENSP00000264554
PRO
P98077
Pharos - Targets
P98077
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