Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SHC2 [cytosol]
Stable Identifier
R-HSA-167050
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC transforming protein 2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
SHC binds to the activated TrkA receptor (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane] (Homo sapiens)
SHC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98077 SHC2
Gene Names
SHC2, SCK, SHCB
Chain
chain:1-582
Reference Genes
BioGPS Gene:25759 SHC2
COSMIC - genes:SHC2 SHC2
CTD Gene:25759 SHC2
dbSNP Gene:25759 SHC2
ENSEMBL:ENSG00000129946 SHC2
HGNC:29869 SHC2
KEGG:hsa:25759 SHC2
Monarch:25759 SHC2
NCBI Gene:25759 SHC2
OMIM:605217 SHC2
UCSC:P98077 SHC2
Reference Transcript
RefSeq:NM_012435.3 SHC2
Other Identifiers
11728145_a_at
16866435
213464_PM_at
213464_at
25759
35622_at
3844568
3844569
3844570
3844572
3844573
3844576
3844580
3844581
3844582
3844583
3844585
3844586
3844587
3844588
3844589
3844600
3844601
3844602
8032037
A_32_P205624
A_33_P3318606
GE53025
GO:0005515
GO:0005829
GO:0005886
GO:0007169
GO:0030971
GO:0035556
HMNXSV003024969
HMNXSV003031939
HMNXSV003041270
Hs.30965.0.A1_3p_at
ILMN_1683857
ILMN_1721087
ILMN_1734667
PH_hs_0037093
RNA94954|RNS_36_198
TC19000985.hg
Participates
as a component of
VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane] (Homo sapiens)
as an input of
p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)
as a member of
SHC [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y-SHC2 [cytosol]
Inferred To
Shc2 [cytosol]
(Mus musculus)
Shc2 [cytosol]
(Rattus norvegicus)
Shc [cytosol]
(Drosophila melanogaster)
SHC2 [cytosol]
(Bos taurus)
SHC2 [cytosol]
(Canis familiaris)
SHC2 [cytosol]
(Gallus gallus)
SHC2 [cytosol]
(Sus scrofa)
shc2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_036567.2
ENSEMBL
ENST00000264554
,
ENSG00000129946
,
ENSP00000264554
OpenTargets
ENSG00000129946
GeneCards
SHC2
HPA
ENSG00000129946-SHC2
ZINC - Substances
SHC2_HUMAN
ZINC target
P98077
PRO
P98077
Pharos - Targets
P98077
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text