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p-Y-SHC2 [cytosol]
Stable Identifier
R-HSA-167051
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-SHC2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)
Activated TrkA receptor:p-SHC [plasma membrane] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Activated TrkA receptor:p-SHC [plasma membrane] (Homo sapiens)
p-Y-SHC [cytosol] (Homo sapiens)
p-Y-SHC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98077 SHC2
Gene Names
SHC2, SCK, SHCB
Chain
chain:1-582
Reference Genes
BioGPS Gene:25759 SHC2
COSMIC (genes):SHC2 SHC2
CTD Gene:25759 SHC2
dbSNP Gene:25759 SHC2
ENSEMBL:ENSG00000129946 SHC2
HGNC:29869 SHC2
KEGG:hsa:25759 SHC2
Monarch:25759 SHC2
NCBI Gene:25759 SHC2
OMIM:605217 SHC2
UCSC:P98077 SHC2
Reference Transcript
RefSeq:NM_012435.2 SHC2
Other Identifiers
11728145_a_at
16866435
213464_PM_at
213464_at
25759
35622_at
3844568
3844569
3844570
3844572
3844573
3844576
3844580
3844581
3844582
3844583
3844585
3844586
3844587
3844588
3844589
3844600
3844601
3844602
8032037
A_32_P205624
A_33_P3318606
GE53025
GO:0005515
GO:0005575
GO:0005829
GO:0005886
GO:0007169
GO:0030971
GO:0035556
HMNXSV003031939
HMNXSV003041270
Hs.30965.0.A1_3p_at
ILMN_1683857
ILMN_1721087
ILMN_1734667
ILMN_1775525
PH_hs_0037093
RNA94954|RNS_36_198
TC19000985.hg
Participates
as a member of
p-Y-SHC [cytosol] (Homo sapiens)
Other forms of this molecule
SHC2 [cytosol]
Inferred To
phospho-Shc2 [cytosol]
(Mus musculus)
phospho-Shc2 [cytosol]
(Rattus norvegicus)
phospho-SHC2 [cytosol]
(Bos taurus)
phospho-SHC2 [cytosol]
(Canis familiaris)
phospho-SHC2 [cytosol]
(Sus scrofa)
phospho-shc2 [cytosol]
(Xenopus tropicalis)
phospho-p-Y-SHC2 [cytosol]
(Gallus gallus)
phospho-Shc [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_036567.2
ENSEMBL
ENST00000264554
,
ENSP00000264554
OpenTargets
ENSG00000129946
HPA
ENSG00000129946-SHC2
ZINC - Substances
SHC2_HUMAN
ZINC target
P98077
PRO
P98077
Pharos - Targets
P98077
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