Reactome | p-6Y-VEGFR2 binds SHC-transforming protein 2

p-6Y-VEGFR2 binds SHC-transforming protein 2

Stable Identifier

R-HSA-4420107

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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p-6Y-VEGFR2 binds SHC-transforming protein 2

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Phosphorylated tyrosine Y1175 of VEGFR2 provides the binding site for the adaptor protein SHC-transforming protein 2 (SHC2) also referred as Shc-like protein (SCK). SCK is plausibly involved in coupling VEGFR2 to ERK (Warner et al. 2000, Ratcliffe et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12214271	Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling Terman, BI, Tao, Q, Ratcliffe, KE, Yavuz, B, Spring, SC, Stoletov, KV	Oncogene	2002
10749680	The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells Knight, EL, Prigent, SA, Feramisco, JR, Lopez-Dee, J, Warner, AJ	Biochem. J.	2000