p-6Y-VEGFR2 binds SHC-transforming protein 2

Stable Identifier
R-HSA-4420107
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated tyrosine Y1175 of VEGFR2 provides the binding site for the adaptor protein SHC-transforming protein 2 (SHC2) also referred as Shc-like protein (SCK). SCK is plausibly involved in coupling VEGFR2 to ERK (Warner et al. 2000, Ratcliffe et al. 2002).

Literature References
PubMed ID Title Journal Year
10749680 The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

Warner, AJ, Lopez-Dee, J, Knight, EL, Feramisco, JR, Prigent, SA

Biochem. J. 2000
12214271 Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling

Ratcliffe, KE, Tao, Q, Yavuz, B, Stoletov, KV, Spring, SC, Terman, BI

Oncogene 2002
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Orthologous Events
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