MyD88 forms a complex with TIRAP:activated TLR2/4

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
MyD88 forms a complex with MAL:activated TLR2/4
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MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex.

Literature References
PubMed ID Title Journal Year
12447441 Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Yamamoto, M, Sato, S, Hemmi, H, Sanjo, H, Uematsu, S, Kaisho, T, Hoshino, K, Takeuchi, O, Kobayashi, M, Fujita, T, Takeda, K, Akira, S

Nature 2002
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Wesche, H, Henzel, WJ, Shillinglaw, W, Li, S, Cao, Z

Immunity 1997
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T, Barton, GM, Flavell, RA, Medzhitov, R

Nature 2002
Participant Of
This event is regulated
Orthologous Events
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