MyD88 forms a complex with TIRAP:activated TLR2/4

Stable Identifier
R-HSA-166072
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane, cytosol
Synonyms
MyD88 forms a complex with MAL:activated TLR2/4
ReviewStatus
5/5
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MyD88 forms a complex with TIRAP:activated TLR2/4
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MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex.

Literature References
PubMed ID Title Journal Year
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Henzel, WJ, Wesche, H, Li, S, Cao, Z, Shillinglaw, W

Immunity 1997
12447441 Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Takeuchi, O, Hoshino, K, Sanjo, H, Fujita, T, Sato, S, Yamamoto, M, Takeda, K, Akira, S, Kaisho, T, Uematsu, S, Kobayashi, M, Hemmi, H

Nature 2002
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Barton, GM, Horng, T, Medzhitov, R, Flavell, RA

Nature 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SOCS1 [cytosol] (Homo sapiens)
Regulator
SIGIRR [plasma membrane] (Homo sapiens)
Orthologous Events
Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Gay, NJ  (2006-04-24)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-08-16)
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