Reactome | SIGIRR [plasma membrane]

SIGIRR [plasma membrane]

Stable Identifier

R-HSA-188067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SIGRR

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6IA17 SIGIRR

Gene Names

SIGIRR, UNQ301/PRO342

Chain

chain:1-410

Reference Genes

BioGPS Gene:59307 SIGIRR

COSMIC (genes):SIGIRR SIGIRR

CTD Gene:59307 SIGIRR

dbSNP Gene:59307 SIGIRR

ENSEMBL:ENSG00000185187 SIGIRR

HGNC:30575 SIGIRR

KEGG:hsa:59307 SIGIRR

Monarch:59307 SIGIRR

NCBI Gene:59307 SIGIRR

OMIM:605478 SIGIRR

UCSC:Q6IA17 SIGIRR

Reference Transcript

Other Identifiers

11734335_a_at

11734336_x_at

11754512_x_at

11763190_x_at

16733858

218921_PM_at

218921_at

227393_PM_at

227393_at

3357778

3357886

3357887

3357888

3357889

3357890

3357891

3357892

3357893

3357894

3357895

3357896

3357897

3357898

3357899

3357900

3357901

3357902

3357903

3357904

3357905

3357906

3357907

3357908

3357910

3357912

3357913

3357915

3357927

3357928

52940_PM_at

52940_at

57647_at

59307

79428_s_at

7945377

A_23_P84344

A_33_P3259705

GE62087

GO:0001960

GO:0005515

GO:0005886

GO:0006953

GO:0006954

GO:0007165

GO:0016020

GO:0031665

GO:0032682

GO:0045751

GO:2000660

HMNXSV003000289

HMNXSV003019956

HMNXSV003026276

HMNXSV003041346

Hs.288455.1.S1_3p_at

ILMN_1736965

ILMN_1748874

ILMN_1762629

ILMN_1807981

PH_hs_0015945

PH_hs_0020077

TC11001231.hg

TC11002980.hg

g11141876_3p_s_at

Participates

as an input of

IL37:IL18R1 binds SIGIRR (Homo sapiens)

as a component of

IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane] (Homo sapiens)

This entity regulates

Negatively

MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)

Inferred To

sigirr [plasma membrane] (Danio rerio)

sigirr [plasma membrane] (Xenopus tropicalis)

SIGIRR [plasma membrane] (Bos taurus)

SIGIRR [plasma membrane] (Canis familiaris)

SIGIRR [plasma membrane] (Gallus gallus)

SIGIRR [plasma membrane] (Sus scrofa)

Sigirr [plasma membrane] (Mus musculus)

Sigirr [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001128526.1, NP_001128525.1, NP_068577.2

Guide to Pharmacology - Targets

2969

ENSEMBL

ENSP00000333656, ENSP00000380756, ENSP00000403104, ENST00000397632, ENST00000431843, ENST00000332725, ENSG00000185187

OpenTargets

ENSG00000185187

GeneCards

SIGIRR

HPA

ENSG00000185187-SIGIRR

PRO

Q6IA17

Pharos - Targets

Q6IA17

GlyGen

Q6IA17

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A6NDB9 PALM3			0.508	4