Expression of Phosphomevalonate Kinase (PMVK)

Stable Identifier
R-HSA-1655839
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Phosphomevalonate Kinase (PMVK)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Phosphomevalonate kinase (PMVK) gene and enhance transcription (Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002). The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
8663599 Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence

Hoffmann, GF, Chambliss, KL, Schreiner, R, Gibson, KM, Slaughter, CA

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SREBP1A,2:NF-Y:SP1:PMVK gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2011-10-13)
Cite Us!