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MT-CYB [mitochondrial inner membrane]
Stable Identifier
R-HSA-164281
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
cytochrome b respiratory subunit of complex III
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex III assembly (Homo sapiens)
Intermediate 0 binds heme and UQCC3 (Homo sapiens)
Intermediate 0 [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Intermediate I [mitochondrial inner membrane] (Homo sapiens)
MT-CYB:heme b [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Intermediate I binds second heme, UQCRB, UQCRQ (Homo sapiens)
Intermediate I [mitochondrial inner membrane] (Homo sapiens)
MT-CYB:heme b [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Intermediate II [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)
Intermediate II [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Late core complex monomer [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Late core complex dimer binds UQCR10, UQCR11, UQCRFS1. (Homo sapiens)
Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Late core complex dimer [mitochondrial inner membrane] (Homo sapiens)
Late core complex monomer [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Late core complex dimerizes (Homo sapiens)
Late core complex dimer [mitochondrial inner membrane] (Homo sapiens)
Late core complex monomer [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Late core complex monomer [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
MT-CYB is translated (Homo sapiens)
Intermediate 0 [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
TTC19 clears UQCRFS1 fragments from Complex III (Homo sapiens)
Cytochrome c reductase [mitochondrial inner membrane] (Homo sapiens)
Complex III monomer [mitochondrial inner membrane] (Homo sapiens)
Complex III catalytic core [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Unknown peptidase cleaves UQCRFS1 subunit (Homo sapiens)
Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane] (Homo sapiens)
Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
Complex III catalytic core [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c reductase [mitochondrial inner membrane] (Homo sapiens)
Complex III monomer [mitochondrial inner membrane] (Homo sapiens)
Complex III catalytic core [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
MT-CYB [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00156 MT-CYB
Gene Names
MT-CYB, COB, CYTB, MTCYB
Chain
chain:1-380
Reference Genes
BioGPS Gene:4519 MT-CYB
COSMIC (genes):MT-CYB MT-CYB
CTD Gene:4519 MT-CYB
dbSNP Gene:4519 MT-CYB
ENSEMBL:ENSG00000198727 MT-CYB
HGNC:7427 MT-CYB
KEGG:hsa:4519 MT-CYB
Monarch:4519 MT-CYB
NCBI Gene:4519 MT-CYB
OMIM:516020 MT-CYB
UCSC:P00156 MT-CYB
Reference Transcript
RefSeq:NC_012920.1 MT-CYB
Other Identifiers
17100683
17100685
4037674
4037678
4037680
4037682
4037684
4037686
4037690
4037691
4037692
4037693
4519
8165690
8165692
A_24_P557534
GO:0001666
GO:0003824
GO:0005215
GO:0005739
GO:0005743
GO:0006091
GO:0006122
GO:0007584
GO:0008121
GO:0009055
GO:0009410
GO:0009636
GO:0009725
GO:0014070
GO:0015990
GO:0016020
GO:0016491
GO:0022900
GO:0022904
GO:0031100
GO:0032991
GO:0033590
GO:0033762
GO:0043226
GO:0044877
GO:0045275
GO:0045333
GO:0045471
GO:0046686
GO:0046688
GO:0046689
GO:0046872
GO:0048856
GO:0051592
GO:0055085
GO:0055093
TC0M000010.hg
TC0M000011.hg
TC0M000025.hg
TC0M000026.hg
Participates
as a component of
Intermediate 0 [mitochondrial inner membrane] (Homo sapiens)
MT-CYB:heme b [mitochondrial inner membrane] (Homo sapiens)
Cytochrome b-heme complex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
Homologues of MT-CYB [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
MT-CYB [mitochondrial inner membrane]
(Bos taurus)
MT-CYB [mitochondrial inner membrane]
(Caenorhabditis elegans)
MT-CYB [mitochondrial inner membrane]
(Danio rerio)
MT-CYB [mitochondrial inner membrane]
(Dictyostelium discoideum)
MT-CYB [mitochondrial inner membrane]
(Drosophila melanogaster)
MT-CYB [mitochondrial inner membrane]
(Gallus gallus)
MT-CYB [mitochondrial inner membrane]
(Mus musculus)
MT-CYB [mitochondrial inner membrane]
(Rattus norvegicus)
MT-CYB [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
MT-CYB [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
MT-CYB [mitochondrial inner membrane]
(Sus scrofa)
BI4 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENSG00000198727
,
ENST00000361789
,
ENSP00000354554
OpenTargets
ENSG00000198727
GeneCards
MT-CYB
HPA
ENSG00000198727-MT-CYB
PRO
P00156
Pharos - Targets
P00156
Orphanet
MT-CYB
HMDB Protein
HMDBP00989
PDB
5XTE
,
5XTI
,
5XTH
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14949 UQCRQ
1
UQCRQ [mitochondrial inner membrane]
(R-HSA-164283)
0.527
2
UniProt:P14927 UQCRB
1
UQCRB [mitochondrial inner membrane]
(R-HSA-164287)
0.527
3
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