Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Insulin effects increased synthesis of Xylulose-5-Phosphate
Stable Identifier
R-HSA-163754
DOI
10.3180/REACT_939.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.
Literature References
PubMed ID
Title
Journal
Year
12110366
Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage
Uyeda, K
,
Yamashita, H
,
Kawaguchi, T
Biochem Pharmacol
2002
Basic Medical Biochemistry: A Clinical Approach, 2nd ed
Lieberman, M
,
Smith, C
,
Marks, AL
2005
3539386
Physiological functions of the pentose phosphate pathway
Wood, T
Cell Biochem Funct
1986
Participants
Events
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
(Homo sapiens)
D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
(Homo sapiens)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
(Homo sapiens)
Participates
as an event of
Integration of energy metabolism (Homo sapiens)
Event Information
Go Biological Process
xylulose biosynthetic process (0005999)
Orthologous Events
Insulin effects increased synthesis of Xylulose-5-Phosphate (Bos taurus)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Caenorhabditis elegans)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Canis familiaris)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Danio rerio)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Dictyostelium discoideum)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Drosophila melanogaster)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Gallus gallus)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Mus musculus)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Rattus norvegicus)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Saccharomyces cerevisiae)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Schizosaccharomyces pombe)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Sus scrofa)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000579
,
BIOMD0000000070
Authored
Gopinathrao, G (2005-05-13)
Created
Gopinathrao, G (2005-05-06)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text