Insulin effects increased synthesis of Xylulose-5-Phosphate

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R-HSA-163754
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Homo sapiens
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One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.

Literature References
PubMed ID Title Journal Year
  Basic Medical Biochemistry: A Clinical Approach, 2nd ed

Marks, AL, Smith, C, Lieberman, M

  2005
12110366 Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage

Uyeda, K, Yamashita, H, Kawaguchi, T

Biochem Pharmacol 2002
3539386 Physiological functions of the pentose phosphate pathway

Wood, T

Cell Biochem Funct 1986
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