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D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
Stable Identifier
R-HSA-163741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Homo sapiens)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-xylulose 5-phosphate and D-ribose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Literature References
PubMed ID
Title
Journal
Year
9357955
Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
Singleton, CK
,
Wang, JJ
,
Martin, PR
Biochim Biophys Acta
1997
Participants
Input
GA3P [cytosol]
SH7P [cytosol]
Output
R5P [cytosol]
XY5P [cytosol]
Participates
as an event of
Insulin effects increased synthesis of Xylulose-5-Phosphate (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
Event Information
Reverse Reaction
ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
Catalyst Activity
transketolase activity of TKT dimer [cytosol]
Physical Entity
TKT dimer [cytosol]
(Homo sapiens)
Activity
transketolase activity (GO:0004802)
Orthologous Events
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Bos taurus)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Caenorhabditis elegans)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Canis familiaris)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Drosophila melanogaster)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Gallus gallus)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Mus musculus)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Rattus norvegicus)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Sus scrofa)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Xenopus tropicalis)
Created
Gopinathrao, G (2005-05-06)
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