triacylglycerol + H2O -> diacylglycerol + fatty acid

Stable Identifier
R-HSA-163551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
triacylglycerol + H2O -> diacylglycerol + fatty acid
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated rat HSL at the lipid particle hydrolyzes triacylglycerol to yield diacylglycerol + fatty acid. In vitro, activated partially purified HSL catalyzes this reaction at only about two times the rate measured with non-activated enzyme (Fredrikson et al. 1981). The much greater rate increase caused by HSL phosphorylation in vivo appears to be due to its phosphorylation-dependent translocation to the surface of the lipid particle (Birnbaum 2003).

HSL-mediated triacylglycerol hydrolysis in humans has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

triacylglycerol lipase activity of phosphorylated HSL dimer:FABP4 complex [lipid droplet]

Physical Entity
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
Activity
triacylglycerol lipase activity (GO:0004806)
Inferred From
triacylglycerol + H2O -> diacylglycerol + fatty acid (Rattus norvegicus)
Authored
D'Eustachio, P  (2005-05-02)
Created
D'Eustachio, P  (2005-05-02)
Cite Us!