triacylglycerol + H2O -> diacylglycerol + fatty acid

Stable Identifier
R-RNO-163515
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
General
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triacylglycerol + H2O -> diacylglycerol + fatty acid
Activated rat HSL at the lipid particle hydrolyzes triacylglycerol to yield diacylglycerol + fatty acid. In vitro, activated partially purified HSL catalyzes this reaction at only about two times the rate measured with non-activated enzyme (Fredrikson et al. 1981). The much greater rate increase caused by HSL phosphorylation in vivo appears to be due to its phosphorylation-dependent translocation to the surface of the lipid particle (Birnbaum 2003).

HSL-mediated triacylglycerol hydrolysis in humans has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Literature References
PubMed ID Title Journal Year
7240206 Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.

Fredrikson, G, Stralfors, P, Nilsson, NO, Belfrage, P

J Biol Chem 1981
Participants
Input
Output
Catalyst Activity

triacylglycerol lipase activity of phosphorylated HSL dimer:FABPA complex [lipid droplet]

Physical Entity
phosphorylated HSL dimer:FABPA complex [lipid droplet] (Rattus norvegicus)
Activity
triacylglycerol lipase activity (GO:0004806)
Orthologous Events
triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)
Authored
D'Eustachio, P  (2005-05-02)
Created
D'Eustachio, P  (2005-05-02)
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