triacylglycerol + H2O -> diacylglycerol + fatty acid

Stable Identifier
R-RNO-163515
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
triacylglycerol + H2O -> diacylglycerol + fatty acid

Activated rat HSL at the lipid particle hydrolyzes triacylglycerol to yield diacylglycerol + fatty acid. In vitro, activated partially purified HSL catalyzes this reaction at only about two times the rate measured with non-activated enzyme (Fredrikson et al. 1981). The much greater rate increase caused by HSL phosphorylation in vivo appears to be due to its phosphorylation-dependent translocation to the surface of the lipid particle (Birnbaum 2003).

HSL-mediated triacylglycerol hydrolysis in humans has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Literature References
PubMed ID Title Journal Year
7240206 Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.

Fredrikson, G, Stralfors, P, Nilsson, NO, Belfrage, P

J Biol Chem 1981
Participants
Catalyst Activity
Catalyst Activity
Title
triglyceride lipase activity of phosphorylated HSL dimer:FABPA complex [lipid droplet]
Physical Entity
Activity
Orthologous Events
Authored
Created
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