Attachment of GPI anchor to uPAR

Stable Identifier
R-HSA-162791
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Attachment of GPI anchor to uPAR
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The mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves the uPAR polypeptide after residue 305, releasing the carboxyterminal peptide of uPAR and replacing it with an acylated GPI moiety. In a second step, the GPI moiety is deacylated, yielding a uPAR-GPI conjugate that can be efficiently transported to the Golgi apparatus.
Literature References
PubMed ID Title Journal Year
1846368 Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.

Ploug, M, Blasi, F, Dano, K, Ronne, E, Behrendt, N, Jensen, AL

J Biol Chem 1991
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Event Information
Go Biological Process
attachment of GPI anchor to protein (0016255)
Orthologous Events
Attachment of GPI anchor to uPAR (Bos taurus)
Attachment of GPI anchor to uPAR (Canis familiaris)
Attachment of GPI anchor to uPAR (Mus musculus)
Attachment of GPI anchor to uPAR (Rattus norvegicus)
Attachment of GPI anchor to uPAR (Sus scrofa)
Authored
D'Eustachio, P  (2005-04-05)
Created
D'Eustachio, P  (2005-04-05)
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