Uncoating of the HIV Virion

Stable Identifier
R-HSA-162585
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Uncoating of the HIV Virion
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HIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, the primary cause seems to be the cytosolic pH and a simple dilution effect. Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane. It is believed that the transiting viral nucleoprotein complex associates with the elements of cytoskeleton like actin microfilaments.
Literature References
PubMed ID Title Journal Year
12091904 Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

Peterlin, BM, Greene, WC

Nat Med 2002
15502876 A hard way to the nucleus

Bukrinsky, M

Mol Med 2004
12417576 Visualization of the intracellular behavior of HIV in living cells

Borisy, GG, Vodicka, MA, McDonald, D, Emerman, M, Svitkina, TM, Lucero, G, Hope, TJ

J Cell Biol 2002
15700618 Early stages of HIV replication: how to hijack cellular functions for a successful infection

Lehmann-Che, J, Saib, A

AIDS Rev 2004
Participants
Events
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as an event of
Event Information
Go Biological Process
uncoating of virus (0019061)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Iordanskiy, S  (2006-04-03)
Bukrinsky, M  (2006-04-03)
Reviewed
Aiken, C  (2006-10-31)
Created
Joshi-Tope, G  (2005-04-01)
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