Reactome | Disassembly of viral capsid

Disassembly of viral capsid

Stable Identifier

R-HSA-173111

Type

Reaction [dissociation]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

cytosol

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Uncoating of the HIV Virion (Homo sapiens)
        
        Disassembly of viral capsid (Homo sapiens)

General

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The HIV capsid protein (p24) surrounds the viral genome and associated proteins to make up the viral core. Dissolution of the viral capsid allows for release of the viral RNA and other proteins such as Vpr into the cytoplasm, which will subsequently form the Reverse Transcription Complex. Dissolution of capsid proteins may be caused by interaction with cellular proteins, e.g. TRIM5, or may occur in a similar fashion to that of matrix dissolution; as a reaction to a change in pH. Indeed, studies observing capsid assembly and conformation show that this protein-protein interaction is heavily influenced by even small changes in pH (pH7.0 to 6.8).

Literature References

PubMed ID	Title	Journal	Year
10881997	Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core Orenstein, J, Zhang, H, Pomerantz, RJ, Dornadula, G	J Hum Virol	2000
11423440	HIV-1 capsid protein forms spherical (immature-like) and tubular (mature-like) particles in vitro: structure switching by pH-induced conformational changes Scarlata, S, Ehrlich, LS, Carter, CA, Liu, T, Chu, B	Biophys J	2001
11264352	Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1 Fassati, A, Goff, SP	J Virol	2001
16292356	The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral Elements Emerman, M, Yamashita, M	PLoS Pathog	2005

Participants

Input

Encapsidated viral core [cytosol] (Homo sapiens)

Output

Participates

as an event of

Uncoating of the HIV Virion (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Iordanskiy, S (2006-04-03)

Bukrinsky, M (2006-04-03)

Reviewed

Aiken, C (2006-10-31)

Created

Gopinathrao, G (2006-02-08)

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