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Disintegration of matrix layer
Stable Identifier
R-HSA-173642
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Uncoating of the HIV Virion (Homo sapiens)
Disintegration of matrix layer (Homo sapiens)
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After fusion of the viral membrane with the target cell membrane, the viral core, which is surrounded by a layer of Matrix (p17) proteins, is exposed to the cytoplasm. Disintegration of the Matrix layer allows for the conical-shaped viral core to be fully released, and allow for viral capsid dissociation and eventually reverse transcription. Dissociation of the Matrix layer is not well characterized, but is believed to occur due to disruption of protein-protein interactions as a result of the conditions of the cytoplasm (including pH), which differ from that of the internal viral structure.
Literature References
PubMed ID
Title
Journal
Year
10881997
Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core
Orenstein, J
,
Zhang, H
,
Pomerantz, RJ
,
Dornadula, G
J Hum Virol
2000
11264352
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1
Fassati, A
,
Goff, SP
J Virol
2001
Participants
Input
Viral core surrounded by Matrix layer [cytosol]
(Homo sapiens)
Output
Encapsidated viral core [cytosol]
(Homo sapiens)
Matrix [cytosol]
(Human immunodeficiency virus 1)
myristoylated nef [cytosol]
(Human immunodeficiency virus 1)
Participates
as an event of
Uncoating of the HIV Virion (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Iordanskiy, S (2006-04-03)
Bukrinsky, M (2006-04-03)
Reviewed
Aiken, C (2006-10-31)
Created
Gopinathrao, G (2006-02-16)
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