CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine

Stable Identifier
R-HSA-1614645
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Cysteine is oxidized
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Oxidation of the thiol moiety of cysteine yields sulfinoalanine, which itself is processed to hypotaurine by an as of yet uncharacterized enzyme in humans . Whether further oxidation of hypotaurine to taurine needs an enzyme is unknown at present (Ye et al. 2007).

Literature References
PubMed ID Title Journal Year
17135237 An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor

Wei, L, Bartlam, M, Tang, D, Ye, S, Rao, Z, Sun, P, Wu, X

J Biol Chem 2007
Participants
Participates
Event Information
Catalyst Activity

cysteine dioxygenase activity of CDO1:Fe2+ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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