CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine

Stable Identifier
R-HSA-1614645
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cysteine is oxidized
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Oxidation of the thiol moiety of cysteine yields sulfinoalanine, which itself is processed to hypotaurine by an as of yet uncharacterized enzyme in humans . Whether further oxidation of hypotaurine to taurine needs an enzyme is unknown at present (Ye et al. 2007).

Literature References
PubMed ID Title Journal Year
17135237 An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor

Ye, S, Wu, X, Wei, L, Tang, D, Sun, P, Bartlam, M, Rao, Z

J Biol Chem 2007
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
cysteine dioxygenase activity of CDO1:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created