MMP14 (MT1-MMP) binds TIMP2

Stable Identifier
R-HSA-1592349
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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MMP14 (MT1-MMP) binds TIMP2
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MMP14 (MT1-MMP) binds tissue inhibitor of metalloproteinases 2 (TIMP2) and has been isolated as a complex from the plasma membrane of HT-1080 cells (Strongin et al. 1995). This complex in turn binds proMMP2 via an interaction of the C-termini of proMMP2 and TIMP2 (Itoh et al. 1998, Butler et al. 1998). Formation of this ternary complex is critical for the subsequent activation of proMMP2.
Literature References
PubMed ID Title Journal Year
7890645 Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

Marmer, BL, Bannikov, G, Collier, I, Strongin, AY, Goldberg, GI, Grant, GA

J Biol Chem 1995
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Orthologous Events
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MMP14 (MT1-MMP) binds TIMP2 (Drosophila melanogaster)
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MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)
MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)
MMP14 (MT1-MMP) binds TIMP2 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-09)
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