Reactome | PPARGC1B [nucleoplasm]

PPARGC1B [nucleoplasm]

Stable Identifier

R-HSA-1592213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PRGC2_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Adipogenesis (Homo sapiens)
  - Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
    - Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
      - CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
      - PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
      - PPARG binds EBF2-bound gene loci (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, PPARGC1A gene) [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:CIDEA gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARGC1A gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
      - PPARGC1A gene expression is stimulated by EBF2 (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
      - PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
      - UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
        
        EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ALAS1 (Homo sapiens)
        
        ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
        
        PPARGC1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86YN6 PPARGC1B

Gene Names

PPARGC1B, PERC, PGC1, PGC1B, PPARGC1

Chain

chain:1-1023

Reference Genes

BioGPS Gene:133522 PPARGC1B

COSMIC (genes):PPARGC1B PPARGC1B

CTD Gene:133522 PPARGC1B

dbSNP Gene:133522 PPARGC1B

ENSEMBL:ENSG00000155846 PPARGC1B

HGNC:30022 PPARGC1B

KEGG:hsa:133522 PPARGC1B

Monarch:133522 PPARGC1B

NCBI Gene:133522 PPARGC1B

OMIM:608886 PPARGC1B

UCSC:Q86YN6 PPARGC1B

Reference Transcript

Other Identifiers

11737101_a_at

11761361_x_at

133522

1553639_PM_a_at

1553639_a_at

1555282_3p_a_at

1555282_PM_a_at

1555282_a_at

16990985

217524_3p_x_at

217524_PM_x_at

217524_x_at

232181_PM_at

232181_at

2835214

2835215

2835217

2835234

2835245

2835246

2835247

2835248

2835249

2835251

2835252

2835253

2835254

2835255

2835256

2835257

2835258

2835259

2835260

2835262

2835263

2835264

2835265

2835266

2835267

2835268

2835270

2835271

2835273

2835274

2835275

2835276

2835277

2835278

2835279

2835280

2835281

2835282

2835287

2835289

2835291

2835293

2835295

60701_r_at

64793_r_at

8109179

81760_at

A_14_P112761

A_14_P129473

A_14_P139459

A_23_P213959

A_24_P560519

A_32_P211188

A_33_P3816688

GE87943

GO:0003676

GO:0003712

GO:0003713

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0008134

GO:0016592

GO:0030331

GO:0030520

GO:0045672

GO:0045944

GO:0050682

GO:0097009

GO:0120162

HMNXSV003027888

HMNXSV003052334

Hs.159475.0.S1_3p_at

Hs2.248652.1.S1_3p_s_at

Hs2.248652.2.S1_3p_a_at

Hs2.248652.2.S1_3p_s_at

ILMN_2195703

PH_hs_0013202

PH_hs_0031920

TC05000823.hg

TC05002689.hg

Participates

as an input of

as a component of

as a member of

PPARGC1A, PPARGC1B [nucleoplasm] (Homo sapiens)

as a candidate of

Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)

Inferred To

ppargc1b [nucleoplasm] (Xenopus tropicalis)

srl [nucleoplasm] (Drosophila melanogaster)

Ppargc1b [nucleoplasm] (Mus musculus)

Ppargc1b [nucleoplasm] (Rattus norvegicus)

PPARGC1B [nucleoplasm] (Bos taurus)

PPARGC1B [nucleoplasm] (Canis familiaris)

PPARGC1B [nucleoplasm] (Gallus gallus)

PPARGC1B [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001166169.1, XP_005268429.1, XP_054207563.1, NP_001166170.1, NP_573570.3

ENSEMBL

ENST00000403750, ENSP00000377855, ENST00000394320, ENSP00000384403, ENSG00000155846, ENST00000309241, ENSP00000353638, ENST00000360453, ENSP00000312649

OpenTargets

ENSG00000155846

GeneCards

PPARGC1B

HPA

ENSG00000155846-PPARGC1B

PRO

Q86YN6

Pharos - Targets

Q86YN6

GlyGen

Q86YN6

PDB

6D0Y, 3SP6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62508 ESRRG	1	ESRRG [nucleoplasm] (R-HSA-446166)	0.659	3

Cite Us!