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PPARGC1B [nucleoplasm]
Stable Identifier
R-HSA-1592213
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PRGC2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARG binds EBF2-bound gene loci (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, PPARGC1A gene) [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:CIDEA gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARGC1A gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1A gene expression is stimulated by EBF2 (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PRDM16 gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:UCP1 gene [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)
ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
ESRRA:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
ESRRA:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
Expression of ATP5B (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
Expression of CYCS (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
PPARGC1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86YN6 PPARGC1B
Gene Names
PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Chain
chain:1-1023
Reference Genes
BioGPS Gene:133522 PPARGC1B
COSMIC (genes):PPARGC1B PPARGC1B
CTD Gene:133522 PPARGC1B
dbSNP Gene:133522 PPARGC1B
ENSEMBL:ENSG00000155846 PPARGC1B
ENSEMBL_homo_sapiens_GENE:ENSG00000155846.17 PPARGC1B
HGNC:30022 PPARGC1B
KEGG Gene (Homo sapiens):133522 PPARGC1B
Monarch:133522 PPARGC1B
NCBI Gene:133522 PPARGC1B
OMIM:608886 PPARGC1B
UCSC:Q86YN6 PPARGC1B
Reference Transcript
RefSeq:NM_001172699.1 PPARGC1B
RefSeq:NM_133263.3 PPARGC1B
RefSeq:XM_005268372.4 PPARGC1B
RefSeq:NM_001172698.1 PPARGC1B
Other Identifiers
11737101_a_at
11761361_x_at
133522
1553639_PM_a_at
1553639_a_at
1555282_3p_a_at
1555282_PM_a_at
1555282_a_at
16990985
217524_3p_x_at
217524_PM_x_at
217524_x_at
232181_PM_at
232181_at
2835214
2835215
2835234
2835247
2835248
2835249
2835251
2835252
2835253
2835254
2835255
2835256
2835257
2835258
2835259
2835260
2835262
2835263
2835264
2835265
2835266
2835267
2835268
2835270
2835271
2835274
2835275
2835276
2835277
2835278
2835279
2835280
2835281
2835282
2835287
2835289
2835291
2835293
2835295
60701_r_at
64793_r_at
8109179
81760_at
A_14_P112761
A_14_P129473
A_14_P139459
A_23_P213959
A_24_P560519
A_32_P211188
A_33_P3816688
GE87943
GO:0001503
GO:0002376
GO:0003676
GO:0003712
GO:0003723
GO:0005634
GO:0005654
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006390
GO:0007010
GO:0007015
GO:0008134
GO:0016592
GO:0023052
GO:0030154
GO:0030331
GO:0030374
GO:0030520
GO:0034614
GO:0042327
GO:0043226
GO:0045672
GO:0045780
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0050682
GO:0060346
GO:0120162
GO:0140053
GO:0140110
HMNXSV003027888
HMNXSV003052334
Hs.159475.0.S1_3p_at
Hs2.248652.1.S1_3p_s_at
Hs2.248652.2.S1_3p_a_at
Hs2.248652.2.S1_3p_s_at
ILMN_2195703
PH_hs_0013202
PH_hs_0031920
TC05000823.hg
TC05002689.hg
Participates
as an input of
NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
as a component of
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
ESRRA:PPARGC1B [nucleoplasm] (Homo sapiens)
as a candidate of
Brown,beige adipocyte-specific coactivators of PPARG:RXRA [nucleoplasm] (Homo sapiens)
Inferred To
ppargc1b [nucleoplasm]
(Xenopus tropicalis)
srl [nucleoplasm]
(Drosophila melanogaster)
Ppargc1b [nucleoplasm]
(Mus musculus)
Ppargc1b [nucleoplasm]
(Rattus norvegicus)
PPARGC1B [nucleoplasm]
(Bos taurus)
PPARGC1B [nucleoplasm]
(Canis familiaris)
PPARGC1B [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001166170.1
,
NP_001166169.1
,
XP_005268429.1
,
NP_573570.3
OpenTargets
ENSG00000155846
GeneCards
Q86YN6
HPA
ENSG00000155846-PPARGC1B
Ensembl
ENST00000309241
,
ENSG00000155846
,
ENST00000360453
,
ENSP00000312649
,
ENSP00000353638
,
ENST00000394320
,
ENSP00000377855
,
ENSP00000384403
,
ENST00000403750
PRO
Q86YN6
Pharos - Targets
Q86YN6
PDB
6D0Y
,
3SP6
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62508 ESRRG
1
ESRRG [nucleoplasm]
(R-HSA-446166)
0.547
2
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